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Index > Protein center > CD2(Gene name) > Human
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  • CD2 (Gene name),
  • T-cell surface antigen CD2 (Protein name ),  CD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD2(SRBC);
    Protein name:
    T-cell surface antigen CD2;
    Alternative:
    LFA-2;Erythrocyte receptor;Rosette receptor;LFA-3 receptor;T-cell surface antigen T11/Leu-5;
    CD:
    CD2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CD2AP (By similarity). Interacts with PSTPIP1.
    Function:
    CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MSFPCKFVAS | FLLIFNVSSK | GAVSKEITNA | LETWGALGQD | INLDIPSFQM | 
    100:
    SDDIDDIKWE | KTSDKKKIAQ | FRKEKETFKE | KDTYKLFKNG | TLKIKHLKTD | 
    150:
    DQDIYKVSIY | DTKGKNVLEK | IFDLKIQERV | SKPKISWTCI | NTTLTCEVMN | 
    200:
    GTDPELNLYQ | DGKHLKLSQR | VITHKWTTSL | SAKFKCTAGN | KVSKESSVEP | 
    250:
    VSCPEKGLDI | YLIIGICGGG | SLLMVFVALL | VFYITKRKKQ | RSRRNDEELE | 
    300:
    TRAHRVATEE | RGRKPHQIPA | STPQNPATSQ | HPPPPPGHRS | QAPSHRPPPP | 
    350:
    GHRVQHQPQK | RPPAPSGTQV | HQQKGPPLPR | PRVQPKPPHG | AAENSLSPSS | 
    351:
    N
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    String:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human T-cell surface antigen CD2
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    ELISA Kit for Human T-cell surface antigen CD2
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    CLIA Kit for Human T-cell surface antigen CD2
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    CLIA Kit for Human T-cell surface antigen CD2
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    96T
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    CLIA Kit for Human T-cell surface antigen CD2
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    Polyclonal Antibody for Human T-cell surface antigen CD2
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    P1576Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human T-cell surface antigen CD2
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    P1576Rb-h
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    Polyclonal Antibody for Human T-cell surface antigen CD2
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    P1576Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human T-cell surface antigen CD2
    Monoclonal Antibody for Human T-cell surface antigen CD2
    Monoclonal Antibody for Human T-cell surface antigen CD2
    Protein for Human T-cell surface antigen CD2
    Protein for Human T-cell surface antigen CD2
    Protein for Human T-cell surface antigen CD2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes."
      Diamond D.J. , Clayton L.K. , Sayre P.H. , Reinherz E.L.
      Proc. Natl. Acad. Sci. U.S.A.85:1615-1619(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure."
      Seed B. , Aruffo A.
      Proc. Natl. Acad. Sci. U.S.A.84:3365-3369(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-266
    3. 3.
      "Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen."
      Sewell W.A. , Brown M.H. , Dunne J. , Owen M.J. , Crumpton M.J.
      Proc. Natl. Acad. Sci. U.S.A.83:8718-8722(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
    5. 5.
      "Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes."
      Sayre P.H. , Chang H.-C. , Hussey R.E. , Brown N.R. , Richardson N.E. , Spagnoli G. , Clayton L.K. , Reinherz E.L.
      Proc. Natl. Acad. Sci. U.S.A.84:2941-2945(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "The structure of the human CD2 gene and its expression in transgenic mice."
      Lang G. , Wotton D. , Owen M.J. , Sewell W.A. , Brown M.H. , Mason D.Y. , Crumpton M.J. , Kioussis D.
      EMBO J.7:1675-1682(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-266
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-266
      tissue: Pancreas.
      tissue: Spleen.
    9. 9.
      "Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)."
      Peterson A. , Seed B.
      Nature329:842-846(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    10. 10.
      "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59."
      Hahn W.C. , Menu E. , Bothwell A.L.M. , Sims P.J. , Bierer B.E.
      Science256:1805-1807(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CD59-BINDING DATA
    11. 11.
      "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion."
      Li J. , Nishizawa K. , An W. , Hussey R.E. , Lialios F.E. , Salgia R. , Sunder-Plassmann R. , Reinherz E.L.
      EMBO J.17:7320-7336(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSTPIP1
    12. 12.
      "Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution."
      Bodian D.L. , Jones E.Y. , Harlos K. , Stuart D.I. , Davis S.J.
      Structure2:755-766(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-206;DISULFIDE BONDS
    13. 13.
      "Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2."
      Withka J.M. , Wyss D.F. , Wagner G. , Arulanandam A.R.N. , Reinherz E.L. , Recny M.A.
      Structure1:69-81(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-129
    14. 14.
      "Conformation and function of the N-linked glycan in the adhesion domain of human CD2."
      Wyss D.F. , Choi J.S. , Li J. , Knoppers M.H. , Willis K.J. , Arulanandam A.R. , Smolyar A. , Reinherz E.L. , Wagner G.
      Science269:1273-1278(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-129
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-217
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